Clinical analysis of one-stage bilateral temporal lobe lesions resection for severe bilateral radiation-induced temporal lobe injury
10.3760/cma.j.cn115354-20191015-00590
- VernacularTitle:一期双侧颞叶病灶切除术治疗双侧严重放射性颞叶损伤的临床疗效分析
- Author:
Leping OUYANG
1
;
Jiahao LIU
;
Mingliang HE
;
Lin XIE
;
Zuoyu HUANG
;
Anmin LIU
Author Information
1. 中山大学孙逸仙纪念医院神经外科，广州 510000
- Keywords:
Radiation-induced brain injury;
One-stage bilateral temporal lobe lesion resection;
Efficacy
- From:
Chinese Journal of Neuromedicine
2020;19(3):273-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the safety and efficacy of one-stage bilateral temporal lobe lesions resection in patients with severe bilateral radiation-induced temporal lobe injury after radiotherapy for nasopharyngeal carcinoma.Methods:Clinical data of 12 patients with severe bilateral radiation-induced temporal lobe injury after radiotherapy for nasopharyngeal carcinoma underwent one-stage bilateral temporal lobe lesions resection in our hospital from January 2013 to December 2017 were retrospectively analyzed. Karnofsky Performance Scale (KPS) scores were used as predictors of surgical outcomes before and two weeks after surgery. Imaging changes of radiation-induced brain injury lesions after surgery before and 3 months after surgery, surgical-related complications, and death were observed.Results:All 12 patients (100%) had improved postoperative KPS scores, which showed significant difference as compared with the preoperative KPS scores ( P<0.05). Two patients had pulmonary infection after operation, one patient had poor wound healing, and one patient had intracranial infection; all of them recovered after expectant treatment. None of the 12 patients had new neurological symptoms after surgery. During the follow-up period, the postoperative cranial MR imaging showed that the lesions were completely removed, and the leukoencephalopathy was alleviated or completely subsided. Conclusion:One-stage bilateral temporal lobe lesions resection is feasible for bilateral radiation-induced temporal lobe injury after radiotherapy for nasopharyngeal carcinoma.
