Risk analysis of vaccination in children with genetic epilepsy combined with febrile seizures plus
10.3760/cma.j.issn.1671-8925.2020.01.011
- VernacularTitle:遗传性癫痫伴热性惊厥附加症患儿的疫苗接种风险分析
- Author:
Xiaoli SHAO
1
;
Jiani HU
;
Yingping YAO
;
Dong YU
;
Zhefeng YUAN
Author Information
1. 浙江省绍兴市人民医院浙江大学绍兴医院儿科 312000
- Keywords:
SCN1A gene;
Epilepsy;
Convulsion;
Vaccine;
Heat-sensitivity
- From:
Chinese Journal of Neuromedicine
2020;19(2):176-180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the risk of vaccination in children with genetic epilepsy combined with febrile seizures plus (GEFS+).Methods Sixty-seven children with GEFS+,admitted to our hospital from May 2016 to May 2019,were enrolled in our study;using targeted second-generation sequencing technology,these patients were divided into positive SCN1A gene mutation group (SCN1A+group,n=l 1) and negative SCN1A gene mutation group (SCN1A-group,n=51) after kicking out 5 patients with other gene mutations.The frequencies of convulsion and changes of body temperature after vaccination were analyzed retrospectively in the two groups from birth to age of 7 years.The levels of interleukin (IL)-2,IL-6,IL-10 and tumor necrosis factor (TNF)-α in peripheral blood were measured by flow cytometry in both groups after seizures.Results Children from SCN1A+ group were vaccinated for 34 times,with incidence of post-vaccine convulsion reaching 47％ (16/34);children from SCN1A-group were vaccinated for 186 times,with incidence of post-vaccine convulsions reaching 6.45％ (12/186);incidence of post-vaccine convulsion was statistically significant between the two groups (P＜0.05).The mean body temperature in children from the SCN1A+ group ([38.06±0.57] ℃C) during convulsion was significantly lower than that in SCN1A-group ([39.49±0.49] ℃,P＜0.05).Expressions of IL-6 and IL-10 in peripheral blood after convulsion in children from SCN1A+ group (96.80±25.05 and 74.90±18.28) were significantly higher than those in SCN1A-group (72.97±4.81 and 43.99±10.63,P＜0.05).Conclusion GEFS+ children in the SCN1A+ group are more prone to convulsion after vaccination than those in the SCN1A-group;cytokines may be involved in the development of convulsion.
