Recent advance in epoxyeicosatrienoic acids in intracerebral hemorrhage
10.3760/cma.j.issn.1671-8925.2020.01.019
- VernacularTitle:环氧二十碳三烯酸在脑出血中的作用研究进展
- Author:
Hongmin WEI
1
;
Jixu YU
;
Zhenchuan LIU
;
Yushuang WANG
;
Huimin ZHU
;
Fengyuan CHE
Author Information
1. 青岛大学第十一临床医学院
- Keywords:
Epoxyeicosatrienoic acid;
Intracerebral hemorrhage;
Soluble epoxide hydrolase;
Arachidonic acid
- From:
Chinese Journal of Neuromedicine
2020;19(1):93-97
- CountryChina
- Language:Chinese
-
Abstract:
Epoxyeicosatrienoic acids (EETs) are mainly from intracellular arachidonic acids catalyzed by cytochrome P450 cyctooxygenase and degraded to lower active dihydroxyeicosapentaenoic acids by soluble epoxide hydrolase.In recent years,EETs have been found to be a new target for prevention and treatment of various nervous system diseases,such as anti-inflammatory reaction,anti-atherosclerosis,anti-cell apoptosis and angiogenesis.Intracerebral hemorrhage is a kind of serious acute cerebrovascular disease.Cerebral hemorrhage is a kind of acute cerebrovascular disease;secondary injury is one of the important mechanisms of cerebral hemorrhage;the present studies have confirmed that EETs have protective role in brain tissues after cerebral hemorrhage,thus,become new hotspot in the research of cerebral hemorrhage.This review focuses on the role and mechanism of EETs in intracerebral hemorrhage,hoping to provide some references for exploration of new research directions and therapeutic targets in the treatment ofintracerebral hemorrhage.
