IL-33 Priming Enhances Peritoneal Macrophage Activity in Response to Candida albicans.
- Author:
Vuvi G TRAN
1
;
Hong R CHO
;
Byungsuk KWON
Author Information
- Publication Type:In Vitro ; Original Article
- Keywords: Peritoneal macrophage; IL-33; Candida albicans; Pro-inflammatory cytokines; Phagocytosis; Fungicidal activity
- MeSH: Bacteria; Candida; Candida albicans*; Fungi; Homicide; Humans; Interleukin-1; Macrophages; Macrophages, Peritoneal*; Phagocytosis
- From:Immune Network 2014;14(4):201-206
- CountryRepublic of Korea
- Language:English
- Abstract: IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.
