Effect of statin pretreatment on collateral circulation and prognoses of patients with cardiac large artery occlusive stroke
10.3760/cma.j.issn.1671-8925.2019.11.011
- VernacularTitle:他汀类药物对心源性大动脉闭塞性脑卒中侧支循环的影响
- Author:
Guoyong REN
1
;
Pan XUE
;
Yingzi MI
;
Longxing ZHANG
;
Jinyan JIAO
Author Information
1. 太原钢铁(集团)有限公司总医院神经内科
- Keywords:
Statin;
Cardioembolic stroke;
Collateral circulation;
Large vessel occlusion;
Cerebral infarction
- From:
Chinese Journal of Neuromedicine
2019;18(11):1142-1145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of statin pretreatment on collateral circulation and prognoses of patients with cardiac large artery occlusive stroke.MethodsFifty-three patients with cardiac large artery occlusive stroke admitted to our hospital from January 2016 to July 2019 were selected. All patients had unilateral middle cerebral artery occlusion. DSA was used to evaluate the collateral flows, and the differences of collateral flows and prognoses in patients took statins before onset were compared with those did not take statins.ResultsAs compared with patients did not take statins, patients took statins had higher incidences of diabetes and coronary heart disease, lower content of low density cholesterol, higher proportion of patients with good collateral circulation (grading 3 to 4), and lower modified Rankin scale scores 3 months after surgery, with statistically significant differences (P< 0.05). Multivariate Logistic regression analysis showed that percentage of patients took statins was independent factors affecting collateral flow in patients with cardiac arterial occlusive stroke(OR=5.000, 95％CI: 1.136-22.006,P=0.033).ConclusionIn patients with cardiac large artery occlusive stroke, statin pretreatment could improve collateral flow and clinical prognoses.
