Establishment of prognosis prediction scale for aspirin combined with clopidogrel in acute cerebral infarction and preliminary evaluation of its prediction effectiveness
10.3760/cma.j.issn.1671-8925.2019.11.010
- VernacularTitle:阿司匹林联合氯吡格雷治疗急性脑梗死预后预测量表的建立及其效果的初步评价
- Author:
Yang LIU
1
;
Panpan JIANG
;
Jia YANG
;
Shan WANG
;
Bing WANG
;
Jianxiong LIU
Author Information
1. 甘肃省人民医院神经外科
- Keywords:
Cerebral infarction;
Aspirin combined with clopidogrel;
Prognosis;
Prediction scale;
Influencing factor
- From:
Chinese Journal of Neuromedicine
2019;18(11):1136-1141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a prognosis prediction scale for aspirin combined with clopidogrel in treatment of acute cerebral infarction (ACI) and evaluate its prediction effectiveness. MethodsA retrospective analysis of clinical features of 202 ACI patients, admitted to and accepted aspirin combined with clopidogrel in our hospital from October 2017 to April 2019, was performed. According to the differences of National Institutes of Health Stroke Scale (NIHSS) scores before and after treatment, the patients were divided into good prognosis group and poor prognosis group; univariate and multivariate Logistic regression analyses were used to screen the independent risk factors for prognoses of acute cerebral infarction; assignment of these factors was performed, respectively, to establish prediction scale; and finally the prediction scale was applied to the patients for verification.ResultsOf the 202 patients, 167 had a good prognosis and 35 had a poor prognosis. Multivariate Logistic regression analysis revealed that age≥50 years, hypertension, homocysteine, and carotid stenosis≥50％ were independent risk factors for prognoses 14 d after onset in patients with ACI (P< 0.05); the assigned values of age≥50 years, hypertension grading I, hypertension grading II, hypertension grading III, homocysteine, and 中华神经医学杂志2019年11月第18卷第11期Chin J Neuromed, November 2019, Vol.18, No.11 carotid stenosis≥50％ were 1, 1, 2, 3, 1, and 1, respectively; the total pridiction scale scores were 0-6. Validation results showed that the poor prognosis rate of patients with predictive scale scores≥3 was 91.3％ (157/172) and that of patients with predictive scale scores<3 was 33.3％ (10/30).Conclusion The predictive scale established in this study can be used to quickly and accurately identify patients with acute cerebral infarction who are suitable for aspirin combined with clopidogrel.
