Recent advances in triggering receptor expressed in myeloid 2 and its role in Alzheimer's disease
10.3760/cma.j.issn.1671-8925.2019.10.017
- VernacularTitle:髓样细胞触发性受体2及其在阿尔茨海默病中的研究进展
- Author:
Jinhuan NING
1
;
Zhaoji LIU
;
Jingzhou LI
;
Dan CAN
;
Yunwu ZHANG
Author Information
1. 厦门大学医学院神经科学研究所暨福建省神经退行性疾病及衰老研究重点实验室
- Keywords:
Alzheimer's disease;
Triggering receptor expressed in myeloid 2;
DAP12
- From:
Chinese Journal of Neuromedicine
2019;18(10):1049-1053
- CountryChina
- Language:Chinese
-
Abstract:
Mutations in the triggering receptor expressed in myeloid 2 (TREM2) gene have recently been found to be closely related to the development of Alzheimer's disease (AD) and other neurodegenerative diseases. However, the detailed mechanism underlying TREM2's participation in the pathogenesis of AD and other diseases has yet to be fully elucidated. In this review, we discuss current understanding on the structure and function of TREM2, the relevance between TREM2 and AD, and the possible causes of AD by TREM2 mutations.
