MR imaging manifestations of acute Li-pilocarpine induced epilepsy rats
10.3760/cma.j.issn.1671-8925.2019.10.012
- VernacularTitle:锂-匹罗卡品诱导癫痫大鼠急性期MRI表现
- Author:
Xiarong GONG
1
;
Kunhua WU
;
Ying ZHAO
;
Lixiang REN
;
Jie ZHANG
;
Hongjiang ZHANG
Author Information
1. 云南省第一人民医院磁共振科
- Keywords:
Epilepsy;
Magnetic resonance imaging;
Diffusion weighted imaging
- From:
Chinese Journal of Neuromedicine
2019;18(10):1035-1037
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the MR imaging findings of Li-pilocarpine-induced acute epilepsy rats and explore the pathophysiological changes of acute epilepsy rats.Methods Twenty-two SD rats were randomly divided into control group (n=9) and model group (n=13). Rats in the model group were intraperitoneally injected with lithium chloride and pilocarpine, while rats in the control group were given equal volume normal saline. All rats were given MR imaging plain scan and diffusion weighted imaging (DWI). The images of rats of the two groups were compared, and the differences of apparent diffusion coefficient (ADC) of the hippocampus, piriform cortex, entorhinal cortex and sensory cortex were compared.Results Four rats in the model group show hyperintensity in T2 weighted imaging and 6 rats in the model group showed hyperintensity in DWI; as compared with T2 weighted imaging, DWI has wider display ranges, mainly distributed in the sensory cortex, and piriform cortex+entorhinal cortex. As compared with those in the control group, the ADC values in sensory cortex and piriform cortex+entorhinal cortex of model group significantly decreased (P<0.05). There were no statistical differences of ADC values in the hippocampus between two groups (P>0.05).Conclusion Multiple regions are involved in acute epilepsy rats, which maybe shown by MR imaging; changes in the somatosensory cortex and piriform cortex+entorhinal cortex may occur before those in the hippocampus.
