Influence of moderate to severe leukoaraiosis in prognoses of acute ischemic stroke patients after endovascular treatment
10.3760/cma.j.issn.1671-8925.2019.10.002
- VernacularTitle:中重度脑白质疏松对急性缺血性脑卒中血管内治疗预后的影响
- Author:
Chao JIANG
1
;
Yaxing LYU
;
Beilei CHEN
;
Jian JING
;
Jun LI
;
Xiaobo LI
Author Information
1. 扬州大学附属苏北人民医院神经内科
- Keywords:
Leukoaraiosis;
Ischemic stroke;
Endovascular treatment;
Prognosis
- From:
Chinese Journal of Neuromedicine
2019;18(10):980-984
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of moderate to severe leukoaraiosis (LA) in prognoses of acute ischemic stroke patients after endovascular treatment.Methods From January 2017 to December 2018, 60 patients with acute ischemic stroke due to anterior circulation large vessel occlusion underwent endovascular treatment and obtained complete vessel recanalization in our hospital were evaluated for degrees of LA severity according to head CT scan and van Swieten scale (2-4 scores were defined as moderate-severe LA). According to modified Rankin scale (mRS) scores 90 d after treatment, the patients were divided into poor prognosis group and good prognosis group. Univariate analysis was used to compare the differences of influencing factors of the two groups. Multivariate Logistic regression analysis was further used to explore the influence of moderate to moderate-severe LA in poor prognosis of patients after endovascular treatment.Results Of the 60 patients, 18 did not have LA, 19 had mild LA, and 23 had moderate-severe LA; 32 had poor prognosis and 28 had good prognosis. Univariate analysis showed that the patients from the poor prognosis group had significantly higher proportion of moderate-severe LA (59. 4％ [19/32]vs. 14.3％ [4/28]), significantly higher baseline National Institutes of Health Stroke Scale (NIHSS) scores ([23.4±10.1]vs. [14.7±7.0]), significantly higher baseline diastolic blood pressure ([87.5±18.9] mmHgvs. [78.3±15.1] mmHg), significantly higherproportion of patients with hypertension history (68.8％ [22/32]vs. 42.9％ [12/28]), and statistically older age ([70.6±9.4] yearsvs. [61.3±12.5] years) than the patients from the good prognosis group (P<0.05). On multivariable Logistic regression analysis, the presence of moderate-severe LA (OR=5.032, 95％CI: 1.026-24.679,P=0.046) and baseline NIHSS scores were independent risk factors for poor prognosis of patients after endovascular treatment.Conclusion Patients with acute ischemic stroke accompanied with moderate-severe LA are more likely to have poor prognosis after endovascular treatment.
