Recent advance in quantitative analysis of iron deposition in Parkinson's disease with MR imaging
10.3760/cma.j.issn.1671-8925.2019.09.017
- VernacularTitle:帕金森病脑铁沉积的MRI定量分析研究进展
- Author:
Kewei LI
1
;
Xueting SUN
;
Zhiwei ZHANG
;
Gang YU
Author Information
1. 重庆医科大学附属第一医院神经内科
- Keywords:
Parkinson's disease;
Iron deposition;
Susceptibility weighted imaging;
Quantitative susceptibility mapping
- From:
Chinese Journal of Neuromedicine
2019;18(9):962-965
- CountryChina
- Language:Chinese
-
Abstract:
The abnormal increase of iron content in the substantia nigra pars compacta of Parkinson's disease (PD) is closely related to dopaminergic neuron injury, which affects the occurrence and development of PD. MRI techniques, including iron concentration-sensitive R2*, Susceptibility Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM), have already applied in the quantification of iron load in brains. MRI techniques have wide application prospects in the early diagnosis, differential diagnosis, monitoring the disease progress and guiding treatment of PD. This article runs retrospective analysis on MRI quantitative research status of iron deposition in brains of patients with PD.