Recent advance in role of macrophage migration inhibitory factor in the central nervous system
10.3760/cma.j.issn.1671-8925.2019.09.015
- VernacularTitle:巨噬细胞迁移抑制因子在中枢神经系统中的作用研究进展
- Author:
Jing YANG
1
;
Yueqian ZHU
;
Hongting ZHAO
;
Hao YAO
Author Information
1. 南京医科大学第二附属医院心血管中心
- Keywords:
Macrophage migration inhibitory factor;
Central nervous system;
Ischemic stroke;
Spinal cord injury
- From:
Chinese Journal of Neuromedicine
2019;18(9):952-956
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage migration inhibitory factor (MIF) is involved in a variety of physiological and pathological processes. Pathological increase of MIF is sufficient to promote inflammation, aggravate metabolic dysfunction, and increase oxidative stress. MIF inhibition, through either gene knockout or pharmacological inhibitors, is clinically beneficial for treatment. Ironically, both detrimental and beneficial effects of MIF have been reported in ischemic stroke, neurodegenerative diseases, and spinal cord injury; thus, the roles of MIF appear to be bidirectional in the central nervous system. In the current review, we focus on the roles of MIF in the central nervous system, as well as its regulating mechanisms.
