Efficacy of double low-profile visualized intraluminal support stent assisted embolization in treatment of acute intracranial wide-neck aneurysms and its relation with levels of soluble intercellular adhesion molecule-1 and S100B
10.3760/cma.j.issn.1671-8925.2019.09.008
- VernacularTitle:双LVIS支架辅助栓塞治疗急性期颅内宽颈动脉瘤的疗效及其与 SICAM-1、S100B水平的关系
- Author:
Huiping YU
1
;
Zhaowen CAI
;
Jianxing HUANG
;
Heping ZHANG
Author Information
1. 福建医科大学附属泉州第一医院神经外科
- Keywords:
Intracranial wide-neck aneurysm;
Double low-profile visualized intraluminal support stent;
Soluble intercellular adhesion molecule-1;
S100B;
Therapeutic effect
- From:
Chinese Journal of Neuromedicine
2019;18(9):922-926
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of double low-profile visualized intraluminal support (LVIS) stent assisted embolization in the treatment of acute intracranial wide-neck aneurysms and its relation with levels of soluble intercellular adhesion molecule-1 (SICAM-1) and S100B. Methods A total of 114 patients with acute intracranial wide-neck aneurysms admitted to our hospital from June 2014 to December 2018 were collected. According to different treatment options, the patients in the study group (n=58) were treated with double LVIS stent-assisted embolization, while those in the control group (n=56) were treated with LVIS stent-assisted embolization. The embolization degrees of intracranial wide-necked aneurysms were evaluated by Raymond grading immediately after surgery, the efficacy of the patients was evaluated by modified Rankin scale (mRS) at discharge, and the serum SICAM-1 and S100B protein levels of the patients with different treatment methods and different curative effects before and after surgery were compared. Results As compared with those in the control group, the degrees of arterial embolization immediately after surgery and good therapeutic effect rate at discharge were significantly higher in the study group (P<0.05). After treatment, the serum levels of SICAM-1 and S100B were significantly lower in the study group than those in the control group (P<0.05). The levels of SICAM-1 and S100B in patients with good therapeutic effect ([147.5±9.8] mg/mL and [0.106±0.027] mg/mL) were significantly lower than those in the patients with poor therapeutic effect ([172.8 ±4.0] mg/mL and [0.158±0.002] mg/mL, P<0.05). Conclusions The embolization rate and therapeutic effect can be significantly improved in patients with acute intracranial wide-neck aneurysms after double-LVIS stent-assisted embolization. The serum levels of SICAM-1 and S100B are significantly increased in patients with poor therapeutic effect.
