Prognostic roles of telomerase reverse transcriptase promoter mutation and 1p/19q co-deletion in newly-diagnosed O6-methylguanine-DNA methyltransferase promoter un-methylated/isocitrate dehydrogenase wild-type glioblastoma multiform
10.3760/cma.j.issn.1671-8925.2019.09.004
- VernacularTitle:TERTp突变和1p/19q联合缺失对新诊断MGMT启动子未甲基化/IDH野生型GBM预后的影响
- Author:
Qiong LU
1
;
Xiwei ZHANG
;
Yang WANG
;
Xiaofang SHENG
;
Xueyong WU
;
Xiaobai WEI
;
Hongyuan GAO
;
Xiaofeng YIN
;
Fang XIE
;
Yueming ZHU
;
Zhonghua JIN
;
Zhenghua ZHANG
;
Haimin WEI
;
Dan LI
;
Renhua HUANG
;
Xianglian WANG
;
Feng XIAO
Author Information
1. 上海市静安区中心医院(复旦大学附属华山医院静安分院)肿瘤科 200040
- Keywords:
Glioblastoma;
O6-methylguanine-DNA methyltransferase;
Isocitrate dehydrogenase;
Telomerase reverse transcriptase promoter mutation and lp/19q co-deletion
- From:
Chinese Journal of Neuromedicine
2019;18(9):896-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic values of telomerase reverse transcriptase promoter (TERTp) mutation and 1p/19q co-deletion in newly-diagnosed O6-methylguanine-DNA methyltransferase (MGMT) promoter un-methylated/isocitrate dehydrogenase (IDH) wild-type glioblastoma multiform (GBM). Methods A total of 82 patients pathologically newly-diagnosed MGMT promoter un-methylated/IDH wild-type GBM, admitted to our hospitals from March 2016 to November 2018, were included in this study. TERTp mutations (TERTp wild-type and TERTp mutation [C228 mutation and C250 mutation]) in GBM specimens were detected by PCR sequencing, 1p/19q co-deletion in GBM specimens was detected by fluorescence in situ hybridization (FISH), and clinical data, adverse reactions and prognoses of patients with different molecular typing were compared. Results There were 33 patients in the TERTp wild type group with mean age of 48 years, and 49 patients in the TERTp mutation group with mean age of 59 years; the difference of age was significant (P<0.05); there were no statistical differences in gender distribution, Karnofsky performance status (KPS) scores, tumor sites and surgical resection degrees between the two groups (P>0.05). There were 8 patients with 1p/19q co-deletion and 74 patients without 1p/19q co-deletion; no significant differences in above clinical parameters were noted between the two groups. There were no statistically significant differences in the incidences of bone marrow suppression, digestive tract response and fatigue, disease progression rate, or survival rate between patients from TERTp wild type group and TERTp mutation group, and between patients with 1p/19q co-deletion and patients without 1p/19q co-deletion (P>0.05). No significant differences in above clinical parameters, disease progression rate, and survival rate were noted between patients with C228 mutation and C250 mutation (P>0.05). Conclusion TERTp typing and 1p/19q co-deletion status do not have prognostic value in newly-diagnosed MGMT un-methylated/IDH wild-type GBM patients; patients with TERTp mutations have older age than wild-type patients; patients with C250 mutation trend to have higher survival rate than those with C228 mutation.
