Recent advance in relation between autophagy and Alzheimer's disease
10.3760/cma.j.issn.1671-8925.2019.08.017
- VernacularTitle:自噬与阿尔茨海默病的相关研究进展
- Author:
Huang KUANG
1
;
Huizhen TIAN
;
Chengyong TAN
;
Lihua LIU
;
Fenfang HONG
;
Shulong YANG
Author Information
1. 南昌大学医学院生理学教研室
- Keywords:
Autophagy;
Alzheimer's disease;
β-amyloid;
Tau protein
- From:
Chinese Journal of Neuromedicine
2019;18(8):842-846
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is characterized byβ-amyloid (Aβ) deposition and tauprotein hyperphosphorylation, whereas its pathogenesis has not been fully known so far. The metabolism of Aβand tau protein is critically affected by autophagy. In the early phase of AD, Aβand tau protein can induce themselves to be eliminated via mTOR-dependent and independent autophagy pathways. In addition, transcription factors EB and apolipoprotein E4 also regulate autophagy and thus participate in the metabolism of Aβand tau protein, affecting AD progression. This review summarized the roles of autophagy in the metabolism of Aβand tau protein and the autophagy regulators closely related to AD in the recent studies.
