Intravenous thrombolytic therapy for cardiogenic and large-artery atherosclerosis stroke: an observational study
10.3760/cma.j.issn.1671-8925.2019.08.008
- VernacularTitle:静脉溶栓治疗CE型与LAA型缺血性脑卒中的观察性研究
- Author:
Weihua ZHANG
1
;
Guangjian ZHAO
;
Lili DONG
;
Binsheng ZHANG
;
Huafang JIA
;
Ziran WANG
;
Hongxing HAN
Author Information
1. 青岛大学第十一临床医学院(临沂市人民医院)神经内科 276000
- Keywords:
Intravenous thrombolysis;
Acute ischemic stroke;
Large artery atherosclerosis;
Cardiogenic stroke;
Outcome
- From:
Chinese Journal of Neuromedicine
2019;18(8):807-812
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the safety and effectiveness of intravenous thrombolysis treatment in large artery atherosclerosis (LAA) and cardioembolic (CE) strokes in patients with acute anterior circulation ischemic stroke.Methods Two hundred and thirty-eight patients with acute anterior circulation ischemic stroke, admitted to and treated with intravenous thrombolysis in our hospital from January 2017 to June 2018 were chosen in our study. These patients were divided into either a LAA group (n=158) or a CE group (n=80) according to etiological subtypes. The differences in baseline data and outcomes 90 d after the onset between the two groups were compared. Baseline data of patients in the good outcome group and the poor outcome group were compared and independent risk factors for poor outcome were determined by multivariate Logistic regression analysis.Results As compared with the patients from the LAA group, patients from the CE group had older age and higher proportion of patients combined with atrial fibrillation, with significant differences (P<0.05); there were no statistically significant differences in the good outcome rate, mortality rate and incidence of symptomatic intracranial hemorrhage between the two groups (P>0.05). Among the 238 patients, 112 were into the good outcome group and 126 were into the poor outcome group; as compared with patients from the poor outcome group, patients from the good outcome group had younger age, and lower National Institute of Health Stroke Scale (NIHSS) scores and lower levels of fasting blood glucose before and after thrombolysis, with statistically significant differences (P<0.05); multivariate Logistic regression analysis showed that older age (odds ratio [OR]=1.040, 95％ confidence interval [CI]: 1.010-1.071,P=0.008) and higher NIHSS scores 24 h after thrombolysis (OR=1.259, 95％CI: 1.175-1.350,P=0.000) were independently associated with poor outcome.Conclusion The outcomes of intravenous thrombolysis in patients with acute anterior ischemic stroke are only associated with age and severity of stroke, and not associated with TOAST etiological subtypes; intravenous thrombolysis for cardiogenic stroke is safe and effective.
