Recent advance in new strategies for therapeutic peptide delivery to the central nervous system
10.3760/cma.j.issn.1671-8925.2019.07.017
- VernacularTitle:治疗性多肽靶向中枢神经系统给药的研究进展
- Author:
Qingjian WU
1
;
Shuyin SUN
;
Houwen CHENG
;
Zifei LI
;
Rongxia XIE
;
Baoliang SUN
Author Information
1. 济宁市第一人民医院急诊科 272011
- Keywords:
Therapeutic peptide;
Central nervous system;
Blood brain barrier
- From:
Chinese Journal of Neuromedicine
2019;18(7):736-739
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of biotechnology, therapeutic peptide has been a hot area in the central nervous system drugs due to its features of easy to design and target specificity. However, therapeutic peptide is difficult to cross the blood brain barrier into the central nervous system and target cells, coupled with its in vivo instability, which seriously restricts its application in central nervous system diseases. This review focuses on the progress of therapeutic peptides across the blood brain barrier targeting the central nervous system, compares and analyses the methods of increasing therapeutic peptides penetration, specificity and stability in combination with other molecules, in order to provide help for the development of central nervous system drugs.
