Recent advance in neurofibromatosis 2 with multi-type tumors
10.3760/cma.j.issn.1671-8925.2019.07.016
- VernacularTitle:Ⅱ型神经纤维瘤病合并多类型肿瘤的最新研究进展
- Author:
Chuiguang KONG
1
;
Xiaosheng HE
Author Information
1. 空军军医大学西京医院神经外科
- Keywords:
Neurofibromatosis Ⅱ;
Neurilemmoma;
Meningioma;
Glioma
- From:
Chinese Journal of Neuromedicine
2019;18(7):732-735
- CountryChina
- Language:Chinese
-
Abstract:
Patients with type Ⅱ neurofibromatosis often have multiple neurological tumors, including schwannoma, meningioma, astrocytoma and ependymoma, of which bilateral vestibular schwannoma is characteristic lesion. More than 90％of familial cases and 80％-85％of sporadic cases of type Ⅱ neurofibromatosis have been confirmed to have neurofibromatosis Ⅱ gene mutations in both tumor tissues and blood. This article reviews the relation of type Ⅱ neurofibromatosis with different types of tumors, and the incidence, natural history and latest treatment strategies of type Ⅱ neurofibromatosis, in order to provide new clues for diagnoses and treatments of patients with type Ⅱ neurofibromatosis complicated with multi-type tumors.
