Recent advance in stem cell transplantation in treatment of traumatic brain injury

VernacularTitle:干细胞移植治疗创伤性颅脑损伤的研究进展
Author: Ji ZHANG ¹ ; Xiaojun ZHANG ; Xuheng JIANG ; Xiaofei HUANG ; Fangke XIE ; Sijia LIU ; Tianjing SUN ; Hongfei GE ; Anyong YU
Author Information

1. 遵义医科大学附属医院急诊科
Keywords: Traumatic brain injury; Stem cell; Neural regeneration; Cell transplantation
From: Chinese Journal of Neuromedicine 2019;18(6):634-638
CountryChina
Language:Chinese
Abstract: Traumatic brain injury (TBI) is one of the diseases with high morbidity,mortality,and disability,which seriously endangers human health.Primary and secondary injuries caused by TBI are cascade reaction of various pathophysiological interactions.Because of its many injury factors and complex mechanisms,the treatment and therapeutic effect of TBI are limited at present.In recent years,animal experiments and clinical studies have shown that stem cell therapy could alleviate TBI-mediated neurological damage to a certain extent.Therefore,activation of endogenous neural cells response and transplantation of exogenous stem cells may be new strategies for TBI treatment.This article reviews the research progress of activation of endogenous neural cells response and transplantation of exogenous stem cells after TBI,and focuses on the therapeutic effects and possible mechanisms of stem cell transplantation in TBI treatment.