Efficacy of moderate dose bromocriptine by one-off oral administration in patients with non-acute prolactin type pituitary adenoma
10.3760/cma.j.issn.1671-8925.2019.06.008
- VernacularTitle:顿服中等剂量溴隐亭对非急症性泌乳素型垂体腺瘤患者的疗效分析
- Author:
Lin WANG
1
;
Shiying LING
;
Cuizhu MEI
;
Ju ZHANG
;
Xufeng CHENG
;
Li JIA
;
Chaoshi NIU
;
Xianming FU
Author Information
1. 中国科学技术大学附属第一医院(安徽省立医院)神经外科
- Keywords:
Bromocriptine;
Prolactin;
Pituitary adenoma;
Curative effect
- From:
Chinese Journal of Neuromedicine
2019;18(6):589-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of moderate dose bromocriptine by one-off oral administration in treatment of patients with non-acute prolactin (PRL) type pituitary adenoma.Methods Forty-three patients with definite diagnosis of non-acute prolactin type pituitary adenoma,admitted to our hospital from January 2016 to December 2017,were chosen in our study.All patients were administrated with 5 mg bromocriptine at 18 pm;the serum PRL levels were examined at 2,3 and 12 h after bromocriptine administration.The curative effects of these patients were judged by decline rate of PRL,and the curative effects of patients with different genders,different initial PRL levels and different ages were compared.Results In these 43 patients,bromocriptine showed excellent effect in 20 patients,obvious effect in 18 and invalid effect in 5.There were statistically significant differences in the efficacy of bromocriptine between different genders (P＜0.05).There were statistically significant differences in efficacy of patients with different genders after taking bromocriptine (P＜0.05).The female patients had obviously higher rate of obvious effect than the male patients.Patients with different initial PRL values had statistically significant differences in efficacy after taking bromocriptine (P＜0.05).Patients with PRL initial value of 40-200 ng/mL had significantly higher rate of obvious effect than patients with PRL initial value of ＞200 ng/mL.There was no significant difference in efficacy between patients ＜ 45 years old and patients＞45 years old (P＞0.05).Conclusion The treatment ofhyperprolactin caused by prolactin type pituitary adenoma with moderate dose bromocriptine by one-off oral administration is effective;female patients have obviously better effect than male patients;and for patients with initial prolactin＞200 ng/mL,the effect is better.
