Expressions of DEAD-box 5 and hepatoma-derived growth factor in glioma samples and their relations with prognoses
10.3760/cma.j.issn.1671-8925.2019.06.007
- VernacularTitle:DDX5和HDGF在胶质瘤中的表达及其与预后的关系
- Author:
Xiaowen LIAN
1
;
Hengxing YOU
;
Zhihao ZHAI
;
Jianliang CHEN
;
Ye SONG
;
Bin LUO
Author Information
1. 中山大学附属第八医院(深圳福田)神经外科
- Keywords:
Glioma;
DEAD-box;
Hepatoma-derived growth factor;
Pathological feature;
Prognosis
- From:
Chinese Journal of Neuromedicine
2019;18(6):583-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of DEAD-box (DDX) 5 and hepatoma-derived growth factor (HDGF) in glioma samples and their relations with prognoses of the patients.Methods Seventy-eight samples from the lesions and 78 samples from the adjacent tissues of glioma patients,admitted to hospital from February 2013 to June 2017,were selected.The protein expressions of DDX5 and HDGF were detected by immunohistochemistry.The positive expression rates of DDX5 and HDGF in the glioma tissues of patients with different clinical characteristics were compared.Kaplan-Meier method was used to plot the survival curves of patients with DDX5 positive expression and DDX5 negative expression;Log-rank test was used to compare the survival rates of these patients.Results Among 78 patients,the positive expression rates of DDX5 and HDGF in the lesion group were 85.9％ and 80.8％,which were significantly higher than those in the paracancerous group (24.4％ and 28.2％,P＜0.05).There were no significant differences in the positive expression rates of DDX5 and HDGF in patients of different genders,ages,or body mass indexes (P＞0.05);patients with tumor size ＞ 3 cm had significantly higher positive expression rates of DDX5 and HDGF as compared with those with tumor size＜3 cm (P＜0.05);patients with WHO grading Ⅲ-Ⅳ had significantly higher positive expression rates of DDX5 and HDGF as compared with those with WHO grading Ⅰ-Ⅱ (P＜0.05);patients with intracranial cerebrospinal fluid metastasis had significantly higher positive expression rates of DDX5 and HDGF as compared with those without intracranial cerebrospinal fluid metastasis (P＜0.05).Log-rank analysis showed that the overall survival of patients from the DDX5 positive expression group was significantly lower than that of patients from the DDX5 negative expression group (P＜0.05).Conclusion DDX5 and HDGF are highly expressed in glioma tissues,and their expressions are related to tumor sizes,WHO grading and intracranial metastasis;patients with positive DDX5 expression have poor prognosis.
