Recent advance in glymphatic system in brain diseases
10.3760/cma.j.issn.1671-8925.2019.05.018
- VernacularTitle:类淋巴系统在脑部疾病中的研究进展
- Author:
Xinyu WANG
1
;
Shanhua DING
;
Qianqian LI
;
Jun WU
Author Information
1. 郑州大学第一附属医院神经内科
- Keywords:
Glymphatic system;
Aquaporin 4;
Brain disease
- From:
Chinese Journal of Neuromedicine
2019;18(5):533-539
- CountryChina
- Language:Chinese
-
Abstract:
The peripheral tissues mainly clear the metabolites through lymphatic system to maintain the homeostasis.In recent years,it has been found that there is a corresponding structure in the brain,namely the glymphatic system,which consists of multiple components,including the para-arterial influx of fluids,the convective bulk of interstitial fluid flow facilitated by aquaporin 4 and the paravenous efflux of fluids;the glymphatic system plays an important role in the removal of metabolites.This article will describe its origin,composition,driving mechanisms and influencing factors,and introduce its corresponding role in the pathological process of brain diseases such as Alzheimer's disease,Parkinson's disease and hydrocephalus.
