Effect of deep brain stimulation of subthalamic nucleus on non-motor symptoms in Parkinson's disease
10.3760/cma.j.issn.1671-8925.2019.04.005
- VernacularTitle:丘脑底核脑深部电刺激对帕金森病非运动症状的治疗效果分析
- Author:
Xiaoxiao LI
1
;
Yang LIU
;
Zimu SONG
;
Tao SUN
;
Lianxiang ZHANG
;
Feng WANG
Author Information
1. 宁夏医科大学总医院神经外科
- Keywords:
Parkinson's disease;
Deep brain stimulation;
Subthalamic nucleus;
Motor symptom;
Non-motor symptom
- From:
Chinese Journal of Neuromedicine
2019;18(4):351-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of deep brain stimulation of subthalamic nucleus (STN-DBS) on non-motor symptoms (NMSs) in patients with Parkinson's disease (PD).Methods Seventeen PD patients,admitted to and accepted bilateral STN-DBS in our hospital from 2012 to 2018,were chosen in our study.Unified Parkinson's Rating Scale (UPDRS) Ⅲ and Non-motor Symptoms Scale (NMSS) were used to evaluate the motor symptoms and non-motor symptoms one week before and 12 months after surgery.The correlations of motor symptoms and non-motor symptoms with age and gender were analyzed.Results The UPDRS Ⅲ total scores of 17 patients were 33.48+10.00 one week before DBS and 10.59±6.70 one year after DBS,with statistically significant difference (P＜0.05).The NMSS total scores were 144.47±51.31 one week before DBS and 86.35±40.23 one year after DBS,with statistically significant difference (P＜0.05).There were statistically significant differences in scores of sleep and fatigue,mental and behavioral abnormalities,sensory abnormality,cognitive impairment and constipation between one week before and one year after surgery (P＜0.05).NMSS scores showed no significant correlation with gender,but showed significant correlations with age,course of disease and Hoehn-Yahr grading (P＜0.05).Conclusion Bilateral STN-DBS can significantly improve some non-motor symptoms to a certain degree.
