Recent advance in dysfunction of mitochondrial dynamics and pathogenesis of Alzheimer's disease
10.3760/cma.j.issn.1671-8925.2019.04.003
- VernacularTitle:线粒体动力学失衡与阿尔茨海默病发病机制的相关性研究进展
- Author:
Chenhao GAO
1
;
Zhengyu SUN
;
Jiewen ZHANG
Author Information
1. 郑州大学人民医院神经内科
- Keywords:
Mitochondrial dynamic;
Alzheimer's disease;
Neuron damage
- From:
Chinese Journal of Neuromedicine
2019;18(4):337-343
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of Alzheimer's disease (AD) has not been fully elucidated.Mitochondria play critical roles in neuronal function;and damage of hippocampal neurons by dysfunction of mitochondrial dynamics is the major pathological mechanism of AD.Improvement of mitochondrial dynamics imbalance in time should alleviate or reverse damage of hippocampal neurons.After a brief overview of basic mechanisms involved in regulation ofmitochondrial fission,fusion,and transportion,and how mitochondrial dynamics affects AD,this review article focuses on discussing the role of key sites such as Drpl,Mfnl/2,Opal and Miro/Milton in regulating mitochondria dynamics and their effects on
