Association between RNF213 rs6565666 polymorphism and intracranial cystic aneurysms in patients from Guangdong Province
10.3760/cma.j.issn.1671-8925.2019.03.004
- VernacularTitle:RNF213基因rs6565666位点多态性与广东省颅内囊状动脉瘤患者 发病的关系
- Author:
Haiyan FAN
1
;
Shenquan GUO
;
Yunchang CHEN
;
Xin ZHANG
;
Xifeng LI
;
Xuying HE
;
Chuanzhi DUAN
Author Information
1. 国家临床重点专科
- Keywords:
RNF213 gene;
Intracranial cystic aneurysm;
Genotype
- From:
Chinese Journal of Neuromedicine
2019;18(3):238-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between RNF213 rs6565666 polymorphisms and intracranial cystic aneurysms in patients from Guangdong province. Methods Two hundred and fifty patients with intracranial cystic aneurysms, admitted to and conformed by digital substraction angiography (DSA) in our hospital from February 2016 to October 2018, were selected as experimental group; and 250 patients without intracranial aneurysms conformed by DSA, CT angiography or magnetic resonance angiography at the same time period were used as control group. The genotypes of rs6565666 locus of RNF213 gene were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR). Results As compared with those in the control group, percentages of AG and AA genotypes were significantly higher and percentage of GG genotype was statistically higher at rs6565666 locus of patients from the experimental group (P<0.05). The proportion of allele A at rs6565666 locus in the experimental group was statistically higher as compared with that in the control group (P<0.05). In the experimental group, 112 patients had ruptured aneurysms and 138 patients did not have ruptured aneurysms; there was no statistically significant difference in the genotype distribution of rs6565666 between the ruptured group and the non-ruptured group (P>0.05). Conclusion RNF213 gene rs6565666 polymorphism is associated with intracranial cystic aneurysms in patients from Guangdong province.
