Recent advance in role of prefrontal cortex in pathogenesis of schizophrenia
10.3760/cma.j.issn.1671-8925.2019.02.016
- VernacularTitle:前额叶皮层参与精神分裂症致病机制的研究进展
- Author:
Jinglan YAN
1
;
Xiaorong ZHENG
;
Yuanjia ZHENG
;
Jiang HE
;
Yongjun CHEN
Author Information
1. 广州中医药大学针灸康复临床医学院华南针灸研究中心
- Keywords:
Prefrontal cortex;
Schizophrenias;
Pathogenesis;
Neurotransmitter;
Neural network
- From:
Chinese Journal of Neuromedicine
2019;18(2):194-198
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia is a serious neurological disorder characterized by incoordination among thinking, cognition, emotion and behavior, and its pathogenesis remains unclear now. In recent years, an increasing number of reports have found that the occurrence of schizophrenia shares a close relationship with prefrontal cortex (PFC), while the later plays an important role in numerous advanced cognitive functions, including working memory, learning and decision making. This review focuses on the recent development of neural circuits, including neurodevelopment, neurotransmitters, synaptic transmission, functional connectivity of brain regions and neural synchrony oscillation in PFC. Hopefully, this review will help to elucidate the pathogenesis of schizophrenia, and provide approaches and ideas for the treatment of relevant psychiatric disorders.
