Efficacy of cognitive intervention in patients with vascular dementia: a Meta-analysis
10.3760/cma.j.issn.1671-8925.2019.02.011
- VernacularTitle:认知干预对血管性痴呆患者作用效果的Meta分析
- Author:
Ying LIU
1
;
Meng YUE
;
Yongming ZOU
Author Information
1. 环湖医院神经内科三病区
- Keywords:
Vascular dementia;
Cognitive intervention;
Meta analysis
- From:
Chinese Journal of Neuromedicine
2019;18(2):170-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of cognitive intervention in general cognitive function, memory ability and ability of daily life in patients with vascular dementia by systematic review. Methods The randomized controlled clinical trials (RCTs) comparing cognitive intervention versus general measurement in patients with vascular dementia were collected through databases, such as PubMed, Embase, JBI Library, Cochrane Library, CINAHL, APA PsyCNET, CNKI and Wanfang Data, from January 2000 to December 2017. The reviewers extracted the data and assessed the quality. And then, RevMan 5.3 software was used for Meta-analysis. Sensitivity analysis and publication bias analysis were performed using Stata 11.0 software and Begg's inspection. Results Fourteen RCTs were included. Meta-analysis showed that as compared with general measurement, cognitive training (mean difference [MD]=2.07, 95％CI: 1.29-2.86, P=0.000), cognitive stimulation (MD=1.63, 95％CI: 0.61-2.65, P=0.002) and cognitive rehabilitation (MD=3.36, 95％ CI: 1.94-4.79, P=0.000) were proved to be effective in improving the general cognitive function. The application of cognitive intervention in patients with vascular dementia could contribute to memory ability (MD=5.53, 95％CI: 1.09-9.97, P=0.010) and ability of daily life (MD=2.85, 95％CI: 0.95-4.74, P=0.000). The sensitivity analysis for studies enrolled in Meta-analysis showed that individual research results were stable, and no significant publication bias was found by Begg's inspection. Conclusion Cognitive intervention in patients with vascular dementia could contribute to their general cognitive function, memory ability and ability of daily life.
