Serum level of 25-hydroxy vitamin D3 and its correlations with sleep quality and cognition in patients with chronic insomnia disorder
10.3760/cma.j.issn.1671-8925.2019.01.013
- VernacularTitle:慢性失眠障碍患者血清25-羟维生素D3的变化对睡眠质量与认知功能的影响
- Author:
Tingting QIAN
1
;
Yingxue LI
;
Jing XU
;
Shanyao ZHU
;
Yijun GE
;
Ping ZHANG
;
Xueyan LI
;
Xiaoyi KONG
;
Guihai CHEN
Author Information
1. 安徽医科大学附属巢湖医院睡眠障碍科
- Keywords:
Insomnia;
25-hydroxy vitamin D3;
Cognitive function
- From:
Chinese Journal of Neuromedicine
2019;18(1):71-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore serum level of 25-hydroxy vitamin D3 (25 [OH]D3) and its correlations with sleep quality and cognitive function in patients with chronic insomnia disorder (CID).Methods Fifty CID patients,admitted to our hospital from October 1,2016 to September 1,2018,and 40 healthy controls were enrolled.Pittsburgh Sleep Quality Index (PSQI) was used to assess insomnia severity (objective sleep status being assessed using polysomnography throughout a night in some patients).Montreal Cognitive Assessment scale (MoCA) was used to evaluate the general cognitive function.Serum level of25(OH)D3 was detected by ELISA.Results As compared with the controls,CID patients had significantly higher PSQI scores (P＜0.05) and statistically higher Hamilton's Depression Scale-17 scores (P＜0.05).The CID patients had significantly lower MoCA scores,having more errors in object work,spatial work and object recognition memorizes in Nine-Box Maze Test than the controls.Partial correlation analysis showed that in CID patients,the level of 25(OH)D3 was negatively correlated with PSQI scores (r=-0.320,P=0.030),spatial working memory errors (r=-0.300,P=0.043) and disease course (r=-0.360,P=0.014),whereas it was positively correlated with total sleep time (r=0.515,P=0.014)and MoCA scores (r=0.422,P=0.003).Conclusion The level of 25 (OH)D3 decreases in the CID patients,which is correlated with insomnia severity and course,and may affect the cognitive function.
