Correlations of focal adhesion kinase and integrin β1 gene single nucleotide polymorphisms with epilepsy

VernacularTitle:粘着斑激酶与整合素β1基因多态性与癫痫的关联研究
Author: Xia LIAN ¹ ; Hekun SHI ; Shu CHEN ; Lili ZENG ; Yan FEI
Author Information

1. 解放军第九○九医院/厦门大学附属东南医院药学科
Keywords: Focal adhesion kinase; Integrin β1; Gene polymorphism; Epilepsy
From: Chinese Journal of Neuromedicine 2019;18(1):39-43
CountryChina
Language:Chinese
Abstract: Objective To analyze the influence of single nucleotide polymorphisms (SNPs) of focal adhesion kinase (FAK) and integrin β1 (ITG β1) in epilepsy seizures.Methods The clinical data were collected from 330 participants (163 epilepsy patientss and 167 normal controls) from January 2017 to May 2018.Peripheral blood was extracted from these patients.The SNPs of FA K genotypes (rs7460,rs10100025,rs7843014,and rs306954) and ITGβ1 genotypes (rs2230395,rs2298141,rs2230394,and rs35016806) were detected by Sequenom MassArray.Logistic regression analysis was used to determine the influence of genotype at each locus in onset of epilepsy.Results The distribution of the 8 genotypes mentioned above accorded with Hardy-Weinberg Equilibrium.There was significant difference in the frequency distribution of FAK genotype rs7843014 between the epilepsy group and normal group (P＜0.05).Logistic regression analysis of FAK genotype rs7843014 could cause epilepsy (OR=1.676,L95=1.100,and P=0.012).Conclusion The mutation of FAK genotype rs7843014 may be one of the risk factors of epilepsy.