Changes of serum amyloid A level and its significance in depression following ischemic stroke
10.3760/cma.j.issn.1671-8925.2018.11.010
- VernacularTitle:缺血性脑卒中后抑郁患者血清淀粉样蛋白A水平检测及其意义研究
- Author:
Zhe CHENG
1
;
Shilong GUO
;
Yan MENG
;
Haorui DU
;
Xinsheng GUO
;
Shichang YANG
Author Information
1. 新乡医学院第二附属医院精神科
- Keywords:
Ischemic stroke;
Post-stroke depression;
Serum amyloid A
- From:
Chinese Journal of Neuromedicine
2018;17(11):1143-1146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of serum amyloid A (SAA) level and its clinical significance in patients with post-stroke depression (PSD). Methods One hundred and sixty-four patients with acute ischemic stroke, admitted to our hospital from January 2016 to June 2017 were assessed with Hamilton Depression Scale-17 (HAMD-17) to evaluate the depression degrees, and accordingly, they were divided into PSD group (n=57) and non-PSD group (n=107). Healthy volunteers who were examined in the corresponding period were selected as healthy control group (n=50). The SAA level was determined with ELISA in subjects of the 3 groups. Clinical data were collected; single factor analysis and multivariate Logistic regression analysis were performed to select the risk factors of PSD. Results The SAA level in PSD group ([18.85±5.25] mg/L) was significantly higher than that in the non-PSD group ([15.25±5.75] mg/L) and healthy control group ([7.65±4.50] mg/L, P<0.05); that in the non-PSD group was significantly higher than that in the healthy control group (P<0.05). Single factor analysis showed that differences in education level, introversion, economic status, living alone, marital status, National Institutes of Health Stroke Scale (NIHSS) scores≥9 at admission, complications, and proportion of key area infarction (frontal lobe and basal ganglia) had statistical significance between PSD group and non-PSD group (P<0.05). Multivariate Logistic regression analysis showed that introversion, poor economic status, living alone, NIHSS scores≥9, infarction of key areas, and elevation of SAA level (OR=1.545, P=0.035, 95％ CI: 1.257-1.898) were independent risk factors for PSD (P<0.05). Conclusion SAA used as one of the detection biomarkers has great significance in early diagnosis, intervention and clinical prevention for PSD.
