Regulation of transcription factors in astrocyte-to-neuron transdifferentiation
10.3760/cma.j.issn.1671-8925.2018.10.020
- VernacularTitle:转录因子调控星形胶质细胞向神经元转分化的研究进展
- Author:
Huajuan TANG
1
;
Xuemei CAI
;
Chenghui NIU
;
Yanbing HAN
Author Information
1. 昆明医科大学第一附属医院神经内科
- Keywords:
Astrocyte;
Transcription factor;
Cell transdifferentiation;
Gene reprogramming
- From:
Chinese Journal of Neuromedicine
2018;17(10):1059-1062
- CountryChina
- Language:Chinese
-
Abstract:
More and more researches demonstrate that astrocytes display the markers of neural stem cells or progenitor cells and have the potential of neural differentiation.Thus,it is possible that astrocytes,especially overactive astrocytes,could replace injured neurons and repair the damaged function by transdifferenting and gene reprogramming.Here,we summarize recent progresses of various transcription factors and their regulation in astrocytes-to-neurons transdifferentiation.
