Relation of angiopoietin-1 with prognoses of patients with acute ischemic stroke
10.3760/cma.j.issn.1671-8925.2018.10.014
- VernacularTitle:血管生成素-1与急性缺血性脑卒中患者预后的关系
- Author:
Liping FANG
1
;
Yangjun FU
;
Jun PENG
;
Shixian MAO
Author Information
1. 434000,荆州市第一人民医院神经内科
- Keywords:
Angiopoietin-1;
Acute ischemic stroke;
Prognosis
- From:
Chinese Journal of Neuromedicine
2018;17(10):1041-1044
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of angiopoietin-1 (Ang-1) with prognoses of patients with acute ischemic stroke.Methods Eighty-nine patients with acute ischemic stroke,admitted to our hospitals fiom October 2015 to December 2017,were chosen.The patients were diagnosed as having acute ischemic stroke by digital subtraction angiography (DSA),and assessed with National Institute of Health Stroke Scale (NIHSS) on the time of admission and 21st d of admission;modified Rankin Scale (mRS) was performed on 90th d of admission.According to NIHSS and mRS scores,these patients were divided into a good prognosis group (difference value of NIHSS scores＞0,mRS scores≤ 2) and a poor prognosis group (difference value ofNIHSS scores≤ 0,mRS scores＞2).In addition,31 patients without acute ischemic stroke who were randomly selected as a control group at the same time.The clinical data of all study subjects were collected.Morning fasting blood of the patients was collected on 2nd,7th,14th,and 21st d of admission.The serum Ang-1 expression was detected by ELISA.Results (1) Fifty-seven patients were into the good prognosis group and 32 were into the poor prognosis group;there were no significant differences in age,gender,hypertension history,diabetes history,smoking history,and drinking history among the control group,good prognosis group and poor prognosis group (P＞0.05).(2) There was no statistically significant difference in Ang-1 expression level in control group among different time points (P＞0.05);however,Ang-1 level in the good prognosis group and the poor prognosis group was the highest on 2n d of admission,and then,gradually decreased,and it still had high expression on the 21st d;significant differences were noted among the 3 groups on 2nd,7th,14th,and 21st d of admission (P＜0.05),and Ang-1 level in the good prognosis group was significantly higher than that in the poor prognosis group and control group (P＜0.05).Conclusion Ang-1 level increases in patients with acute ischemic stroke;Ang-1 level in good prognosis patients is higher than that in poor prognosis patients,suggesting that Ang-1 may be related to their prognoses.
