Association of dopamine receptor D2 TaqIA gene polymorphism with persistent postural-perceptual dizziness
10.3760/cma.j.issn.1671-8925.2018.10.012
- VernacularTitle:多巴胺受体D2TaqIA基因多态性与持续性姿势-知觉性头晕的相关性研究
- Author:
Zhihui YAN
1
;
Liping CUI
;
Tianxia YU
;
Jianhua TANG
;
Min KONG
;
Quntao YU
;
Hui LIANG
;
Chunfu CHEN
Author Information
1. 烟台山医院神经内科
- Keywords:
Dopamine receptor D2;
TaqIA gene;
Persistent postural-perceptual dizziness
- From:
Chinese Journal of Neuromedicine
2018;17(10):1033-1036
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association ofdopamine receptor D2 (DRD2) TaqIA gene polymorphism with persistent postural-perceptual dizziness (PPPD) and explore the molecular mechanism of this disease.Methods The study group consisted of 43 patients diagnosed as having PPPD was chosen in our hospital from January 2017 to June 2017;45 gender-and age-matched control subjects were selected randomly from acute vertigo patients who were fully recovered within 3 months without selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) medication and were normal at 6 months of follow up.Personality characteristics of the two groups were analyzed by adult Essen personality inventory.Frequencies of DRD2 TaqIA gene polymorphism were detected with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Results Percentage of neurotic individuals in study group (67.4％) was significant higher than that of control subjects (37.8％,P＜0.05).Genotype distribution ofA1/A1,A1/A2,and A2/A2 showed significant difference between the two groups (P＜0.05).In the study group,A1 and A2 allele frequencies in the DRD2 TaqIA gene were 65.1％ and 34.9％ respectively,which had significantly difference as compared with those of control subjects (46.7％ and 53.3％,P＜0.05).Conclusion A 1 allele in DRD2 TaqIA gene may be the susceptibility gene for PPPD.
