Comparative study of efficacy and safety of direct thrombectomy and bridging therapy for acute large-vessel occlusion in anterior circulation stroke
10.3760/cma.j.issn.1671-8925.2018.10.006
- VernacularTitle:急性前循环大血管闭塞性脑卒中直接机械取栓与桥接治疗的疗效及安全性的对比研究
- Author:
Zongjie SHI
1
;
Sujie ZHENG
;
Tianming SHI
;
Jie PAN
;
Yu GENG
Author Information
1. 浙江省人民医院(杭州医学院附属人民医院)神经内科
- Keywords:
Stroke;
Direct thrombectomy;
Bridging therapy
- From:
Chinese Journal of Neuromedicine
2018;17(10):1003-1007
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of direct thrombectomy and bridging therapy for acute large-vessel occlusion in anterior circulation stroke.Methods A retrospective study was performed on clinical data of 146 patients with anterior circulation large-vessel occlusion stroke who accepted direct thrombectomy in our hospital from March 2016 to July 2017;85 patients were in direct thrombectomy group and 61 patients were in bridging therapy group.The clinical characteristics,procedural complications and clinical outcomes between the two groups were compared.Results There were no significant differences between the two groups in age,gender,baseline National Institutes of Health Stroke Scale (NIHSS) scores,percentages of patients with hypertension,diabetes and atrial fibrillation,baseline blood glucose,platelet count,creatinine level,baseline systolic blood pressure,stroke etiology,occlusion site,and anesthesia methods (P＞0.05).There were no significant differences between the two groups in admission-to-CT time,admission-to-puncture time,puncture-to-re-canalization time,and admission-to-re-canalization time (P＞0.05).The successful reperfusion rate (91.8％ vs.95.1％),incidence of symptomatic intracranial hemorrhage (11.8％ vs.21.3％),favorable outcome rate 90 d after treatment (41.2％ vs.47.5％),and mortality (20.0％ vs.18.0％) were not significantly different between the two groups (P＞0.05).Conclusion The efficacy and safety of direct thrombectomy and bridging therapy are similar for acute large-vessel occlusion in anterior circulation stroke.
