Correlations of a disintegrin and metalloproteinase with thrombospondin type 1 motifs gene polymorphisms with vulnerability of carotid plaque and lipid-loweringing efficacy of atorvastatin in patients with cerebral infarction
10.3760/cma.j.issn.1671-8925.2018.10.005
- VernacularTitle:ADAMTS-1基因多态性与脑梗死患者颈动脉粥样硬化性斑块易损性及阿托伐他汀降脂疗效的相关性研究
- Author:
Chenling LYU
1
;
Chao CHEN
;
Zhengzhong ZHANG
;
Zhou ZHENG
;
Xiaoping JIN
Author Information
1. 浙江省立同德医院神经内科
- Keywords:
A disintegrin and metalloproteinase with thrombospondin type 1 motifs;
Genetic polymorphism;
Cerebral infarction;
Carotid artery;
Atherosclerosis;
Plaque vulnerability;
Atorvastatin;
Lipid-lowering therapy
- From:
Chinese Journal of Neuromedicine
2018;17(10):997-1002
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations ofa disintegrin and metalloproteinase with thrombospondin type 1 motifs (ADAMTS1) gene single nucleotide polymorphism (SNPs) with vulnerability of carotid plaque formation and atorvastatin lipid-efficacy in patients with cerebral infarction.Methods Seven hundred and seventy-eight patients with anterior circulation infarction,admitted to our hospital from June 2010 to June 2015,were divided into the following 3 groups according to their carotid ultrasound examination results:vulnerable plaque group (n=291),stable plaque group (n=286) and no plaque group (n=201).Atorvastatin was given in patients from the 3 groups and the low density lipoprotein cholesterin (LDL-C) level was detected to evaluate the atorvastatin lipid-efficacy in 151 patients from vulnerable plaque group 4 weeks after treatment.The SNPs of rs402007 (G/C) in ADAMTS1 gene of all patients were detected by PCR amplification and DNA sequencing.Results There were statistically significant differences in age,fibrinogen (FIB) level,homocysteine (HCY) level and percentage of patients having diabetes among the three groups (P<0.05).The frequencies of GC+CC genotype and C allele in rs402007 (G/C) ofADAMTS1 gene in the vulnerable plaque group were significantly higher as compared with those in the no plaque and vulnerable plaque groups (P<0.05).After adjusting risk factors (age,FIB,HCY and diabetes),GC+CC genotype was the independent risk factor of vulnerable plaque (OR=1.559,P=0.015,95%CI:1.089-2.232).There were no significant differences in LDL-C levels before and after atorvastatin treatment among the GG,GC,and CC genotypes in vulnerable plaque group (P>0.05).Conclusion C allele in ADAMTS1 gene might increase the risk of plaque's instability;no correlation exists between A DAMTS1 gene polymorphisms and LDL-C lowing efficacy to atorvastatin.