Association between breast cancer susceptibility gene associated RING domain-1 single-nucleotide polymorphisms and neuroblastoma: a Meta-analysis
10.3760/cma.j.issn.1671-8925.2018.09.013
- VernacularTitle:BARD1基因单核苷酸多态性和神经母细胞瘤关联性的Meta分析
- Author:
Min MA
1
;
Chengyao WANG
Author Information
1. 武汉大学中南医院麻醉科
- Keywords:
Breast cancer susceptibility gene associated RING domain-1 gene;
Single-nucleotide polymorphism;
Neuroblastoma;
Meta-analysis
- From:
Chinese Journal of Neuromedicine
2018;17(9):940-944
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess and synthesize the current evidence on association of rs6435862 and rs3768716 single-nucleotide polymorphisms (SNPs) of breast cancer susceptibility gene associated RING domain-1 (BARD1) gene and neuroblastoma (NB) susceptibility.Methods Five electronic databases including PubMed,Embase,Web of Science,CNKI and Wanfang were searched for potentially relevant studies on the association of BARD1 SNPs and NB from precious to May 10,2018.Main information of included studies was extracted after literature selection.Newcastle-Ottawa Scale (NOS) was employed for quality assessment.RevMan5.3 software was used to analyze the association of rs6435862 and rs3768716 SNPs and NB susceptibility under allelic model,homozygous model,heterozygous model,dominant model,as well as recessive model.Results Five case-control studies with 9 independent cohorts comprising 3597 NB patients and 10827 healthy controls were yielded for Meta-analysis.For NOS,each included study obtained no less than 6 stars and was labeled of high quality.The findings indicated that rs6435862 and rs3768716 polymorphisms had significant association with NB susceptibility under five genetic models (P＜0.05).Conclusion Rs6435862 and rs3768716 SNPs of BARD1 gene are significantly associated with NB;G-allele and GG-genotype carriers appear to have an increased risk of NB susceptibility.
