Recent advance in role of RNA binding protein in glioma

VernacularTitle:RNA结合蛋白在胶质瘤中的研究进展
Author: Jun ZHANG ¹ ; Kaikai WANG ; Shiguang ZHAO
Author Information

1. 哈尔滨医科大学附属第一医院神经外科
Keywords: Glioma; RNA binding protein; Cancer
From: Chinese Journal of Neuromedicine 2018;17(9):892-896
CountryChina
Language:Chinese
Abstract: Glioblastoma (GBM) is one of the most common primary malignant intracranial tumors and has a poor prognosis despite the application of standard therapies-surgical resection,radiotherapy and chemotherapy.RNA-binding proteins (RBPs) are proteins that directly bound to RNA.They could regulate RNA splicing,polyadenylation,localization,stability and translation by creating functional units called ribonucleoprotein complexes (RNPs).RBPs play an important role in tumor progression including glioma.In this paper,we summarized the recent development of research of RBPs in glioma progress,especially the molecular mechanism of RBPs regulating RNA biological activity.