Evaluation and modification of clinical absolute and relative scale system for myasthenia gravis
10.3760/cma.j.issn.1671-8925.2018.07.011
- VernacularTitle:重症肌无力绝对与相对评分法的改良与评价研究
- Author:
Yao XU
1
;
Ling HUANG
;
Hong CHEN
;
Fang XU
;
Shimin YIN
;
Yan LU
;
Lei WANG
Author Information
1. 锦州医科大学火箭军总医院研究生培养基地
- Keywords:
Myasthenia gravis;
Absolute and relative scale;
Modified absolute and relative scale;
Validity;
Reliability
- From:
Chinese Journal of Neuromedicine
2018;17(7):710-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the validity and reliability of modified absolute and relative scale for myasthenia gravis (mARS-MG),and explore its clinical application value in evaluating the severity of MG.Methods One hundred and three MG patients,admitted to our hospital from March 2016 to February 2017,were enrolled in our study.A new measurement called mARS-MG was put forward,which had modified the items about bulbus medullae of ARS-MG.In mARS-MG,chewing and swallowing were split into 2 items.The swallow function was measured by water swallow test.An experienced neurologist performed 4 scales,ARS-MG,mARS-MG,Quantitative Myasthenia Gravis scale (QMG) and Myasthenic Muscle Scale (MMS),on these patients.Spearman correlation analysis was performed to assess the correlations of ARS-MG,mARS-MG,QMG,and MMS scores.Validity of ARS-MG and mARS-MG was constructed and evaluated by structural equation modeling.Besides,Cronbach's alpha coefficient was used to evaluate the internal consistency of the scales.Results Strong correlations were noted among ARS-MG,mARS-MG and QMG,MMS scores ([r[＞0.800,P＜0.05).The items in each scale were grouped according to different muscle groups;strong correlations among ARS-MG,mARS-MG,QMG and MMS scores were found in bulbus medullae,limbs and respiratory muscle (|r|＞0.900,P＜0.05).In the extraocular muscles' part,the correlations were also well (|r|＞0.650,P＜ 0.05);however,the correlations in facial part between these scales were not well.The chewing and swallowing items were highly correlated to QMG and MMS scores (|r|＞0.900,P＜0.05).Besides,the items of ARS-MG and mARS-MG were all reasonable;these two scales had good construct validity;the reliability analysis showed that the intemal consistency of ARS-MG and mARS-MG was good (Cronbach's α＞0.8).Conclusion Both ARS-MG and mARS-MG showed good validity and reliability in evaluating the severity of MG patients;they are all suitable for further promotion and clinical application,and the modified version is better than the original one in the bulbar part.
