Roles of growth differentiation factor 10 in nervous system
10.3760/cma.j.issn.1671-8925.2018.06.022
- VernacularTitle:生长分化因子10在中枢神经系统中的作用
- Author:
Sijia LI
1
;
Jianping WANG
;
Kefei CUI
;
Lie YU
;
Xiaojie FU
Author Information
1. 郑州大学第五附属医院神经内科
- Keywords:
Growth differentiation factor 10;
Cerebellar development;
Stroke;
Neuralgia
- From:
Chinese Journal of Neuromedicine
2018;17(6):645-648
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have demonstrated that superfamily of transforming growth factor-β (TGF-β) plays vital roles in the development of nervous system and neurological diseases.Growth differentiation factor l 0 (GDF 10) is one of the most prominent members of this superfamily.GDF 10 has been shown to participate in tissue formation during cerebellar development and be closely related to the outcomes of neuralgia,ischemic stroke and other neurological diseases.These findings provide novel ideas for research into pathogenesis of nervous system diseases and targets for development of new therapeutic approaches.This article reviews biochemical structure of GDFI0,its downstream signaling pathways,and its roles in cerebellar development,neuralgia and ischemic stroke.Also the possible neurological diseases that may be treated by GDF10 are listed.
