Recent advance in gene polymorphisms of inflammatory cytokines in Alzheimer's disease
10.3760/cma.j.issn.1671-8925.2018.06.021
- VernacularTitle:炎性因子的基因多态性在阿尔茨海默病中的研究进展
- Author:
Qiangian LI
1
;
Lanjun LI
;
Danhua DING
;
Shuang ZHANG
;
Jun WU
Author Information
1. 郑州大学第一附属医院神经内科
- Keywords:
Alzheimer's disease;
Inflammatory cytokines;
Gene polymorphisms
- From:
Chinese Journal of Neuromedicine
2018;17(6):640-644
- CountryChina
- Language:Chinese
-
Abstract:
The central nervous system inflammatory response plays an important role in the pathogenesis of AD.Pro-inflammatory cytokines can induce inflammatory reactions in the body,enhance the neurotoxic effects caused by Aβ,promote the pathogenesis of AD and anti-inflammatory factors can down-regulate the inflammatory response,play a protective role and promote the reconstruction of damaged tissue.However,due to the existence of genetic polymorphisms,the influence of inflammatory factors on AD is complicated,especially in different population groups.Studing and clarifying the relationship between gene polymorphisms of inflammatory factors and and the pathogenesis of AD will promote the study of the mechanism of AD and provide a new method for the treatment of AD.Therefore,this article mainly reviews this.
