Role and clinical significance of Miro GTPases in mitochondrial transport in neurons
10.3760/cma.j.issn.1671-8925.2018.05.020
- VernacularTitle:Miro蛋白在神经元线粒体转运中的作用及临床意义
- Author:
Yeli ZHU
1
;
Weiyi YU
;
Haishan JIANG
Author Information
1. 南方医科大学南方医院神经内科
- Keywords:
Miro GTPases;
Neurons;
Mitochondrial transport;
Neurological diseases
- From:
Chinese Journal of Neuromedicine
2018;17(5):529-532
- CountryChina
- Language:Chinese
-
Abstract:
Neurons,the basic unit of nervous system,are highly polarized cells with unique physiological functions.Mitochondrial dynamics are critical to neurons,involving fission and fusion,transport and distribution,synthesis and degradation.Mitochondrial transport helps maintain local energy supply.Mitochondrial long-distance movements are facilitated by their coupling to microtubule-based transport via the transport complex.The core component of this complex is mitochondrial Rho GTPases Miro.In this review,we focus on the Miro's role in mediating mitochondrial transport in neurons and its relation to neurological diseases.
