Research progress concerning miRNAs regulating autophagy in ischemic brain injury
10.3760/cma.j.issn.1671-8925.2018.04.018
- VernacularTitle:miRNAs调控自噬在缺血性脑损伤中的研究进展
- Author:
Yanan CUI
1
;
Shixin XU
;
Junping ZHANG
;
Nannan ZHANG
;
Yalu LIU
;
Lanlan CAO
Author Information
1. 天津中医药大学研究生院
- Keywords:
miRNAs;
Autophagy;
Ischemic brain injury
- From:
Chinese Journal of Neuromedicine
2018;17(4):415-418
- CountryChina
- Language:Chinese
-
Abstract:
miRNAs,as a class of endogenous small noncoding RNAs,have come to be a new treatment target for ischemic brain injury as many of them have been discovered to participate in multiple links of the injury.Autophagy,a catalysis process based on lysosomes,has become a current research hotspot because it has been found to participate in and regulate the pathological process of ischemic brain injury.As regulation of autophagy by miRNAs represents a new post-transcriptional regulatory mechanism,autophagy miRNAs after ischemic brain injury have attracted growing interest trom researchers worldwide.It is expected that the role of miRNAs in autophagy regulation can be clarified with the research progress and new therapeutic targets and directions can be found for the treatment of ischemic brain injury.This review gives a brief summary of the research progress conceming the role of miRNAs in regulating autophagy after ischemic brain injury,hoping the information may promote understanding of the important effects and potential therapeutic values of miRNAs-regulated autophagy in ischemic brain injury.
