A study of prospective memory in patients with Parkinson's disease and emotional apathy
10.3760/cma.j.issn.1671-8925.2018.04.009
- VernacularTitle:伴情感淡漠的帕金森病患者前瞻性记忆研究
- Author:
Jing YANG
1
;
Guoping WANG
;
Qiqiang TANG
Author Information
1. 中国科学技术大学附属第一医院神经内科
- Keywords:
Emotional apathy;
Parkinson's disease;
Cognitive impairment;
Prospective memory
- From:
Chinese Journal of Neuromedicine
2018;17(4):376-380
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of prospective memory in patients with Parkinson's disease (PD) and emotional apathy.Methods Included in this study were 62 PD patients who had sought medical attention at our department from January 2015 to January 2017.They were divided into an emotional apathy group and a normal emotion group according to the emotional indifference scale.Also included in this study were another 35 healthy controls matched for demographic data.Their neurological function status,severity of illness and demographic data were assessed using the Unified Parkinson's Disease Rating Scale and the General Questionnaire.The neuropsychological tests and experimental paradigms of event-based prospective memory (EBPM) and time-based prospective memory (TBPM) were used to assess their cognitive function and prospective memory.Comparisons were done between the 3 groups in the above measurements.Results (1) Neuropsychological tests demonstrated that the 2 groups of PD patients had significantly lower MoCA scores and significantly higher HAMA and Stroop scores than the healthy control group (P＜0.05).The emotional apathy group had significantly higher HAMA,Stroop and digit span test (DST) scores than the normal emotion group (P＜0.05).(2) In EBPM task,the emotional apathy group scored significantly lower than the normal emotion group and the 2 groups of PD patients scored significantly lower than the healthy control group (P＜0.05).In TBPM task,the emotional apathy group scored significantly lower than the normal emotion group and the healthy control group (P＜0.05).(3) The correlation analysis showed that the EBPM scores were negatively correlated with the HAMD,Stroop and DST scores in the emotional apathy group (r=-0.352,P=0.048;r=-0.515,P=0.003;r=-0.524,P=0.002).Conclusion Prospective memory impairment may be more severe in PD patients with emotional apathy,suggesting an impact of their emotional apathy on their prospective memory.
