Biodegradable flow-diverting stent for treatment of saccular wide-neck aneurysm in rabbits
10.3760/cma.j.issn.1671-8925.2018.03.009
- VernacularTitle:可吸收聚乙醇酸血流导向支架治疗兔宽颈动脉瘤的实验研究
- Author:
Kuizhong WANG
1
;
Qiang LIU
;
Lubin YAN
;
Shaoji YUAN
;
Zhenqiang HAO
;
Tianzhu WANG
;
Peigang LU
Author Information
1. 济南军区总医院神经外科
- Keywords:
Biodegradable flow-diverting stent;
Intracranial aneurysm;
Polyglycolic acid
- From:
Chinese Journal of Neuromedicine
2018;17(3):263-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility of biodegradable flow-diverting stent for treatment of intracranial wide-neck aneurysm.Methods Twenty adult New Zealand rabbits were used to induce wide-neck aneurysm models by elastase,and then,these models were divided into 3 groups:in group one (n=7),biodegradable polyglycolic acid flow-diverting stents (PGA-FDs) were implanted into parent arteries and covered the necks of aneurysms;in group 2 (n=7),the bare metal FDs replaced PGA-FDs;the observation period of animals in group one and group 2 was 3 months;in group 3 (n=6),the PGA-FDs were implanted into parent arteries with 6 weeks of observation period.The status of aneurysm occlusion and patency of side branches covered by the stent were assessed,and all animals were sacrificed:HE staining was used to observe the thrombosis in the aneurysms,Elastic fiber staining was used to observe the neointimal thickness of parent arteries,and immuohistochemical staining was employed to detect the expressions of CD34,CD68 and alpha-actin (αSMA) in the parent arteries.Results Complete aneurysm occlusion rate in groups one,2 and 3 was 83.3％ (5/6),0％ (0/6) and 66.7％ (4/6),respectively.The neointimal thickness in parent artery of groups one,2 and 3 was (111±69) μm,(70±48) μm and (190±52) μm,respectively;that in group 3 was significantly higher than that in group one and 2 (P＜0.05).The neointima comprised predominantly smooth muscle cells and collagen fibers.Some CD34 positive vascular endothelial cells could be seen in the neointima of parent arteries of groups one and 2.Conclusion The PGA-FD is an effective device to occlude aneurysms without inducing obvious neointimal thickness and side branch stenosis in the 3-month follow-up.
