Risk factors of progressive motor deficit in patients with acute middle cerebral artery occlusion beyond thrombolysis time
10.3760/cma.j.issn.1671-8925.2018.02.011
- VernacularTitle:溶栓时间窗外急性大脑中动脉闭塞患者进展性运动功能缺损的危险因素分析
- Author:
Xuanjun LIU
1
;
Guoshuai YANG
;
Yanhui ZHOU
;
Qihui CHENG
;
Haili LIN
;
Lyu ZHOU
;
Yanjun ZHANG
;
Yujie HU
Author Information
1. 中南大学湘雅医学院附属海口医院神经内科
- Keywords:
Middle cerebral artery occlusion;
Progressive motor function deficit;
Beyond thrombolysis time;
Risk factor
- From:
Chinese Journal of Neuromedicine
2018;17(2):165-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of progressive motor deficit (PMD) in patients with acute middle cerebral artery occlusion (MCAO) beyond thrombolysis time.Methods The clinical data of 123 patients with acute MCAO beyond thrombolysis time,admitted to our hospital from March 2015 to March 2017,were analyzed retrospectively.According to whether patients having National Institute of Health Stroke Scale (NIHSS) scores increased＞2 within 5 d of admission and continued for 24 h,these patients were divided into two groups:PMD group and non-PMD group.Single factor analysis was performed on all clinical parameters that might influence PMD;in addition,the influencing factors of PMD were analyzed by multiple factor Logistic regression analysis.Results Fifty-one patients (41.5％) had PMD and 72 patients (58.5％) did not have PMD.Single factor analysis showed that the differences of randomized blood glucose level,ratio of patients with PH2 type hemorrhagic transformation,intracurricular infarct pattern,radiation crown infarct and collateral circulation pathway between the PMD group and the non-PMD group were statistically significant (P＜0.05).Multiple factor Logistic regression analysis showed that ratio of patients with PH2 type hemorrhagic transformation,radiation infarct site,internal watershed infarct model and collateral circulation pathway were significantly correlated to PMD (OR=2.857,95％CI:1.037-7.869,P=0.042;OR=2.585,95％CI:1.219-5.481,P=0.013;OR=2.876,95％CI:1.327-6.232,P=0.007;OR=2.332,95％CI:1.120-4.867,P=).024).Conclusion PH2 type hemorrhagic transformation,corona radiate infarct,intemal watershed infarct model and insufficient collateral circulation pathway are the important risk factors of PMD in patients with acute MCAO beyond thrombolysis time.
