Gamma knife irradiation-induced trigeminal somatosensory evoked potentials changes in trigeminal nerves of rabbits
10.3760/cma.j.issn.1671-8925.2018.02.007
- VernacularTitle:伽玛刀照射兔三叉神经后TSEP变化的实验研究
- Author:
Yifeng CHENG
1
;
Dong LIU
;
Desheng XU
;
Yongqing ZONG
;
Youlin GE
Author Information
1. 天津医科大学第二医院神经外科伽玛刀中心
- Keywords:
Gamma knife;
Trigeminal nerve;
Trigeminal somatosensory evoked potential
- From:
Chinese Journal of Neuromedicine
2018;17(2):142-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation of gamma knife radiation doses and changes of trigeminal nerves after gamma knife irradiation by studying the changes of trigeminal somatosensory evoked potentials (TSEP) characteristics oftrigeminal nerve roots irradiated by gamma knife in normal animals.Methods Fifteen New Zealand rabbits were divided into 60 Gy irradiation group,80 Gy irradiation group,100 Gy irradiation group,120 Gy irradiation group and control group in accordance with random number table (n=3).The first 4 groups used Gamma Plan 5.34 planning system to design the radiation targets and radiation doses.The target was placed at trigeminal nerve root entry zone,bilateral irradiation was performed,and the central dose was divided into 60 Gy,80 Gy,100 Gy and 120 Gy.The bilateral TSEP was monitored before and 6 months after irradiation.The monitoring data were recorded and statistical analysis was performed.Results P1,N1,P2 wave latencies,P1-N1,N1-P2 interpeak latencies and amplitudes in the 60 Gy irradiation group after irradiation showed no significant differences as compared with those in the control group (P＞0.05);P1,N1,P2 wave latencies,P1-N1,N1-P2 interpeak latencies and amplitudes in the 80 Gy irradiation group,100 Gy irradiation group,and 120 Gy irradiation group after irradiation showed significant differences as compared with those in the control group (P＜0.05),and these changes increase with increase of doses.Conclusion The changes of TSEP,which increase with increase of doses,are closely related to the doses of gamma knife irradiation,of which 80 Gy is the lowest dose to produce changes.
