Efficacy and safty of preventive antibiotics for stroke associated pneumonia in patients with acute stroke: a Meta analysis
10.3760/cma.j.issn.1671-8925.2018.01.015
- VernacularTitle:预防使用抗菌药物对脑卒中相关性肺炎有效性和安全性的Meta分析
- Author:
Xiaonian HAN
1
;
Jing HUANG
;
Xiaotao JIA
;
Kangkang YAN
;
Xin ZAN
;
Li MA
Author Information
1. 710003,西安市中心医院药剂科临床药学室
- Keywords:
Antibiotic;
Prophylaxis;
Stroke associated pneumonia;
Meta-analysis
- From:
Chinese Journal of Neuromedicine
2018;17(1):78-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine if preventive antibiotics is effective in stroke associated pneumonia in patients with acute stroke.Methods Medline (January 1950 to January 2017),EMBASE (January 1974 to January 2017),Cochrane Library (January 2009 to January 2017),CNKI (January 1979 to January 2017)and Wanfang data (January 1998 to January 2017) were searched for randomized controlled trial comparing preventive antibiotics with placebo/blank controls for stroke associated pneumonia in patients with acute stroke.The included studies were screened out strictly based on the criterion of inclusion and exclusion.The quality of included studies was evaluated and the data were extracted by two researchers independently.RevMan 5.1 was used for Meta analysis.Results A total of 4 studies involving 3894 patients were included.The results of Meta-analysis indicated that there was no significant difference in the incidence of stroke associated pneumonia between preventive antibiotics and control groups (OR=0.96,95％CI:0.72-1.29,P=0.810);and there were no statistically significant differences in mortality (OR=1.05,95％CI:0.88-1.25,P=0.570) and good outcome (modified Rankin scale ≤ 2,OR=1.02,95％CI:0.89-1.17,P=0.780).There were no serious adverse reactions related to the studied drugs in 4 studies.Conclusion Preventive antibiotics could neither reduce the incidence of stroke associated pneumonia nor decrease the mortality or improve the proportion of good outcome.
