Efficacy comparison of hippocampal transection and traditional approaches in treatment of medial temporal lobe epilepsy
10.3760/cma.j.issn.1671-8925.2018.01.012
- VernacularTitle:海马横切术与其他传统术式治疗颞叶内侧型癫痫的疗效比较
- Author:
Quanjun ZHAO
1
;
Wei WANG
;
Jia WANG
;
Tao WANG
;
Shaojie CUI
;
Tiejun SHI
;
Peixin WANG
;
Lianfeng LI
;
Bo HEI
Author Information
1. 解放军第三○六医院立体定向及脑功能性疾病诊治中心
- Keywords:
Epilepsy;
Hippocampal transection;
Anterior temporal lobectomy;
Selective amygdalo-hippocampectomy
- From:
Chinese Journal of Neuromedicine
2018;17(1):62-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the outcomes of seizure control by three different surgical approaches,hippocampal transection,anterior temporal lobectomy and selective amygdalo-hippocampectomy,for the treatment of intractable medial temporal epilepsy,and explore their influences in the impairments of cognitive and memorial functions.Methods Twenty-nine patients with intractable medial temporal epilepsy,admitted to our hospital from January 2012 to October 2015,were chosen in our study;8 patients accepted hippocampal transection,10 accepted anterior temporal lobectomy and 11 accepted selective amygdalo-hippocampectomy.Seizure controls after treatment with these 3 approaches were compared and results of neuropsychological examinations (verbal intelligence quotient [VIQ],performance intelligence quotient [PIQ],full intelligence quotient [FIQ] and memory quotient [MQ]) were compared before and after operation.Results The effective rates of seizure controls were all higher than 80％ and seizure free rate was about 60％ in the 3 groups;Engel grading showed no significant differences among the three groups (P＞0.05).Results of all the neuropsychological examinations in the hippocampal transection group before and after operation had no significant differences (P＞0.05);however,all results in the anterior temporal lobectomy group after operation were significantly declined as compared with those before operation (P＜0.05);and PIQ,FIQ and MQ scores in the selective amygdalo-hippocampectomy group after operation were significantly lower as compared with those before operation (P＜0.05).Conclusions Hippocampal transection will not cause significant damage in intelligence and memory functions.As compared with both anterior temporal lobectomy and selective amygdalo-hippocampectomy,hippocampal transection can have good seizure control and preserve memory function.
