Single-stage total corpus callosotomy combined with different resective operations in children with Lennox-Gastaut syndrome
10.3760/cma.j.issn.1671-8925.2017.12.020
- VernacularTitle:胼胝体全段一期切开联合多种切除性手术治疗Lennox-Gastaut综合征(附九例报道)
- Author:
Kangping MA
1
;
Bojing TAN
;
Linhua YI
;
Guangbiao QIN
;
Yucheng YANG
;
Yunlin LI
Author Information
1. 首都儿科研究所附属儿童医院神经外科
- Keywords:
Lennox-Gastaut syndrome;
Total corpus callosotomy;
Epilepsy
- From:
Chinese Journal of Neuromedicine
2017;16(12):1290-1293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the outcomes of Lennox-Gastaut syndrome (LGS) with single-stage total corpus callosotomy combined with different resective surgeries. Methods Nine LGS patients, admitted to our hospital from May 2010 to May 2014, were chosen in our study. Their clinical data were retrospectively analyzed. According to the results of anatomy, electrophysiology and clinical comprehensive evaluation, all the 9 children received single-stage total corpus callosotomy combined with different resective operations. The differences of epileptic seizures of these children before and after surgery were compared. Results The 9 LGS children were followed up for 2 years;5 achieved Engel grade I, 3 achieved Engel grade II, and one achieved Engel grade III. The surgical effective rate was 88.9％ (8/9). The frequencies of drop seizures, convulsive seizures, tonic seizures and tonic-clonic seizures were decreased of different degrees, with drop seizures enjoying the best control. Three patients had transient silence, remarkable relief one week after surgery and total recovery half year after surgery. Conclusion Early single-stage total corpus callosotomy combined with different resective operations can help to control seizures in children with intractable LGS.
