Recent advance in nod-like receptor protein 3 inflammasome and Alzheimer's disease
10.3760/cma.j.issn.1671-8925.2017.11.021
- VernacularTitle:NLRP3炎性复合体在阿尔茨海默病中的研究进展
- Author:
Yue DAI
1
;
Fangfang HU
;
Yonghai LIU
;
Guiyun CUI
;
Xia SHEN
;
Zuohui ZHANG
Author Information
1. 徐州医科大学附属医院神经内科
- Keywords:
Alzheimer's disease;
Amyloid β-protein;
Inflammation;
Nod-like receptor protein 3 inflammasome
- From:
Chinese Journal of Neuromedicine
2017;16(11):1178-1183
- CountryChina
- Language:Chinese
-
Abstract:
Neuroinflammation plays a pivotal role in Alzheimer's disease (AD).A growing number of studies proved that nod-like receptor protein 3 (NLRP3) inflammasome was involved in the neuroinflammation of AD through multiple mechanisms,which are crucial to the initiation and development of AD.In this paper,we will summarize the role ofNLRP3 inflammasome and its potential mechanism in AD pathogenesis,as well as NLRP3 inflammasome inhibitors.
