Comparison of exosomes and microparticles specificities and their roles in central nervous system
10.3760/cma.j.issn.1671-8925.2017.11.020
- VernacularTitle:外泌体与微粒的特异性比较及在中枢神经系统中的作用研究进展
- Author:
Yiming SONG
1
;
Wanqiang SU
;
Rongcai JIANG
Author Information
1. 天津医科大学总医院神经外科
- Keywords:
Exosome;
Microparticle;
Central nervous system
- From:
Chinese Journal of Neuromedicine
2017;16(11):1174-1177
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are homogeneous membrance-derived microvesicles shed by cells,their sizes ranged from 40 to 100 nm.As for microparticles,they are small heterogeneous vesicles at diameters of 100 to 1000 nm shed by cells.Both of them exist in a wide range of body fluids,including peripheral blood,urine,saliva,ascites,amniotic fluid and cerebrospinal fluid,with various kinds of biomolecules like proteins and RNAs.Exosomes and microparticles play important roles in cell-to-cell information transmissions and substance exchanges,contributing to both physiological and pathological processes.Exosomes,functioning as the carders of material transportation,serve as targeted therapy in disease treatments.Microparticle,a new type biomarker,plays an important role in diagnosing the early-stage of diseases and predicting the prognoses.The central nervous system diseases are lacked of early-stage diagnoses and effective treatments because of the complexity and unpredictability.This review is to focus on the specific comparisons between exosomes and microparticles as well as their central nervous system functions and mechanisms,and also to explore the new treatments of the central nervous system diseases.
